Fig. 1

General synthesis procedure to fabricate a magnetic nanosensor from a magnetic nanoparticle. Production of the magnetic particle core entails providing the magnetic material and protecting it against dissolution or changes. Core shell geometries with silica, polymer or carbon coatings are the most frequently applied layers connecting the magnetic core with the biochemical functionality. After application of a linker, a specificity creating moiety must be attached. Suitable entities are antibodies, nucleic acids and other biomolecules