Fig. 6

In vivo CEST imaging nanomedicines intravenous injected in mice bearing MDA-MB-231 breast of cancer xenografts. The imaging showed that the nanomedicine was mainly accumulated in tumor areas and peaked at 1 h (a, n = 2), 2 h (b, n = 4), and 2.5 h (c, n = 2) after tail intravenous injection; The relative MTRasym at 0.5 ppm for muscle and entire tumor for the two groups, respectively (d, e). (**p < 0.01, paired t test)