Fig. 6
From: Nanovaccine-based strategies for lymph node targeted delivery and imaging in tumor immunotherapy
Cationic surface of nanoplatforms for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. A Schematic representation of cationic PSA micelles loaded with a Trp2 peptide that were delivered to the draining LNs. The in vivo distribution of PSA showed accumulation in the draining LNs and low systemic spread. B Fluorescence imaging of various organs and tissues. C Confocal laser scanning microscopy showed the co-distribution of green fluorescence in draining lymph nodes. (Adapted with permission from [62]. Copyright © 2014 Elsevier B.V. All rights reserved.) D Schematic illustration of the MXP nanoplatform loaded DCs and promoting LN-targeting and activating the DC-based antitumor immune cascade. E The MXP@OC vaccine enhances lymphatic drainage of DCs. (Adapted with permission from [75]. Copyright © 2023. The Zhang et al. Wiley‐VCH GmbH)