Fig. 7
From: Nanovaccine-based strategies for lymph node targeted delivery and imaging in tumor immunotherapy
Deformability of nanoplatforms affects LN targeting. A Confocal image of PPAS droplets. B SIM image of antigen-adsorbed PPAS droplets. C QCM-D analysis and corresponding SIM images of the pliability of PPAS and PMPs on the membrane-coated chips. D Presence of migrated antigens and quantitative fluorescent intensity of antigens in the draining LNs. (Adapted with permission from [93]. Copyright © 2018, Springer Nature Limited.) E Schematic illustration showing that the soft nanovaccine promotes LN targeting and evokes robust DC-mediated antitumor immune responses. F Schematic illustration and optical imaging of in vivo lymphatic drainage of the nanovaccines. (Adapted with permission from [67]. Copyright © 2022, Wiley–VCH.)