Fig. 7
From: Advances in nanomedicines for lymphatic imaging and therapy
Copyright © 2021 American Association for the Advancement of Science
Preparation and anticipated tumor inhibition mechanism of macrophage-tumor chimeric exosomes. Biologically reprogrammed macrophage-tumor chimeric exosomes were constructed by introducing tumor nuclei into activated macrophages (aMT-exos). This strategy generated exosomes with tumor components as well as classical activated macrophage (M1) properties, including tumor-antigen-MHC molecules, co-stimulatory molecules, immune-activated cytokines and other tumor components [101].