Fig. 1

Characterization of C2@mLMP2. A Chemical structure of C2. B Preparation of C2@mRNA-LNP. C TEM image of C2@mLMP2. D Fluorescence microscope of DC2.4 cells transfected by C2@mRNA, Lipo2k@mRNA, and naked mRNA. E Luminescence of the transfected DC2.4 cells in the FITC channel. F Cy5 mRNA in C2@Cy5-mRNA escapes from lysosomes sufficiently after administration in DC2.4 cells. G, H Antigen expression in vivo