Fig. 4

Cellular uptake and intracellular Dox release of DOX@GNCs and B7H3/DOX@GNCs in NCI-H1299 cells. A, C Flow cytometry analysis of the cellular uptakes of DOX, DOX@GNCs, and B7H3/DOX@GNCs (1 μg/mL) with incubation for 12 h. B, D Flow cytometry analysis of the cellular uptakes of B7H3/DOX@GNCs (1 μg/mL) after incubation at a different time. E CLSM images of cells treated with GNCs, DOX, DOX@GNCs, B7H3@GNCs, and B7H3/DOX@GNCs (1 μg/mL) for 12 h