Fig. 4
In vivo distribution of exoscFv and exoctrl in PC9 tumor-bearing mice. (A) Schematic diagram of the experimental procedure. 200 µg exoscFv, 200 µg exoctrl or PBS were injected via the tail vein into PC9 tumor-bearing mice, n = 3 mice per group, exosomes dosage = 10 mg/kg. (B) Whole-body images of the exosome distribution. Images obtained at indicated time intervals after injection, n = 3 mice per group. (C) Changes in fluorescent intensity of tumor site over time, n = 3. (D) Ex vivo fluorescence imaging of the distribution of the DiD-labeled exosomes in organs at 96 h after injection. (E) Fluorescence images of tumor cryosections were obtained by confocal fluorescence imaging (Red: DiD, Blue: DAPI), Scale bar = 150 μm