Fig. 5
In vivo distribution of exoscFv and exoctrl in PC9 BM model. (A) Whole-body images of the exosome distribution. Images obtained at indicated time intervals after injection, n = 3 mice per group, exosomes dosage = 10 mg/kg. (B) Changes in fluorescent intensity of brain part over time, n = 3. (C) Ex vivo fluorescence images of major organs at 24 h after injection. (D) Ex vivo fluorescence images of BM model. (E) Fluorescence images of tumor cryosections were taken by confocal fluorescence imaging (Red: DiD, Blue: DAPI). Scale bar = 750 μm (left), 150 μm (middle), 75 μm (right)trl. (F) Quantification of the fluorescence signal intensity in Fig. 5E. ****p < 0.0001, Data were expressed as mean ± SD, n = 5