Fig. 6

ePL increases heart glucose uptake in vivo. a Representative PET/CT images from experiments on ¹⁸F-FDG tracer uptake in mice pre-injected with ePL or PBS vehicle control. b Quantification of ¹⁸F-FDG tracer uptake in different organs, using the standardized uptake values (SUV). c Molecular structure of fluorescent glucose analog, 2-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-D-glucosamine (NBDG). d Injection schedule of NBDG and ePL in experiments with in vivo glucose uptake and competition with unlabeled glucose. e Whole organ fluorescence imaging after ePL-NBDG experiments as depicted in d. f The fluorescence in the hearts of animals from e was quantified after background subtraction and normalized to the organ weight (n = 4 mice per group). g Proposed mechanisms of action of ePL. ePL increases circulation half-life of AAV, glucose heart uptake and reduces liver off-target effects