Fig. 1
From: Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN
Inhibition of growth and proliferation of Ph+ leukemia cell lines by OA2-siRAPSYN. a The effects of OA2-siRAPSYN on mRNA level of RAPSYN gene and protein level of RAPSYN, after the Ph+ leukemia cell lines were treated with OA2-siNC or OA2-siRAPSYN for 24 h; b The effects of OA2-siRAPSYN on the viability of leukemia cell lines; c The effects of OA2-siRAPSYN on the apoptosis of leukemia cell lines; d The effects of OA2-siRAPSYN on the proliferation of K562 cells; e The effects of OA2-siRAPSYN on BCR-ABL neddylation and the expression of the proteins involved in Wnt/β-catenin/c-Myc signaling pathway. Statistical analyses were performed by student T-test. Data are presented as mean ± SD (n = 3). ns: no significance, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus control