Fig. 6

In vivo tumor therapy. (a) Scheme illustrating the establishment and treatment of the 4T1 tumor-bearing Balb/c mice. (b, c) Body weight changes (b) and tumor volume (c) curves of 4T1 tumor-bearing Balb/c mice after different treatments. (d) The records of tumor volume of mice with indicating treatments (n = 6). (e, f) Photographs (e) and weights (f) of the tumors from different groups after 14 days treatments. (g) Percent inhibition rate of tumor weight. (1), (2), (3), and (4) indicate the groups of control, ActD, FessMOF-PEG, and FessMOF/ActD-PEG, respectively. (h, i) H&E (h) and TUNEL (i) staining of tumor slices after treatments. Scale bars are 20 μm. All data were presented as mean ± standard deviation. Statistical differences were calculated using two-tailed Student’s t test. Differences were considered significant when the p-value was less than or equal to 0.05. * p < 0.05, ** p < 0.01, and **** p < 0.0001