Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy

Zhang, Xiaojie; Liang, Qiangwei; Cao, Yongjin; Yang, Ting; An, Min; Liu, Zihan; Yang, Jiayu; Liu, Yanhua

doi:10.1186/s12951-024-02598-y

Fig. 8

From: Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy

The percentage of CD11b⁺Gr-1⁺ MDSCs (A, a), CD11c⁺CD80⁺ DCs, CD11c⁺CD86⁺ DCs (E, e), CD4⁺CD8⁺ T cells (B, b), NK1.1⁺ (C, c), CD25⁺Foxp3⁺ Tregs (F, f), F4/80⁺CD206⁺ TAMs and F4/80⁺CD86⁺ TAMs (D, d) in different formulations treated-4T1 tumors. Data were expressed as mean ± SD (*p < 0.05, **p < 0.01, n = 3). (G) Immunofluorescence staining analysis of MDSCs, CD4⁺CD8⁺ T cells and CCR7, and the immunohistochemistry analysis of COX-2 and HMGB1 expressions in different formulations treated-4T1 tumors. The scale bar is 100 μm

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Fig. 8

Journal of Nanobiotechnology

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