Fig. 10
Self-produced hydrogen gas-powered magnesium micro-motor for the treatment of rheumatoid arthritis and acute ischemic stroke [215, 216]. A Schematic diagram of Mg-HA motor driven by self-produced hydrogen actively producing hydrogen under the guidance of ultrasound for RA treatment. B Schematic illustration of the fabrication of Mg–HA motors. C Schematic illustration of HPMs fabrication. D Mechanism of the H2-mediated RA curative effect by Mg–HA motors. Active H2 alleviates RA progression by ROS scavenging and further attenuates inflammation along with inflammatory cytokines. E Schematic illustration of HPMs as in situ H2 generator for ischemic stroke remedy by active H2 delivery to scavenge ROS and alleviate oxidative stress