Table 5 Application of nanoregulators to reduce tissue ischemia reperfusion

Micro/nano motor-MG micromotor

Arthritic rats

Improve joint injury and inhibit the severity of overall arthritis

Hydrogen produced by magnesium contact with water pushes the motor forward; hydrogen removes inflammatory substances and reactive oxygen species from tissues and reduces oxidative stress damage to tissues

[215]

Middle cerebral artery occlusion in rats

The area of cerebral infarction was significantly reduced and the ability of spatial learning and memory was improved in rats

Mentioned above

[216]

Nano-enzyme: cysteine copper nano enzyme coated with albumin

Sperm

Sperm motility increased and apoptosis decreased

Scavenging ROS and reducing oxidative stress produced by reactive oxygen species

[217]

Ultraminiature Cu5.4O-based nanoparticles

Mouse

Significantly improve the therapeutic effects of various ROS-mediated injuries such as acute renal injury, acute liver injury, and wound healing

At the same time, it has the characteristics of catalase, superoxide dismutase, and glutathione peroxidase mimics enzymes and efficiently scavenges ROS

[218]

New gold and platinum nanoparticles

Renal ischemia–reperfusion injury model in mice

Attenuate ischemia–reperfusion injury in mice

Through the release of oxygen, it can improve cell proliferation, apoptosis, and glucose uptake under hypoxia

[219]