Fig. 5
From: Steering the course of CAR T cell therapy with lipid nanoparticles
Efficiency of LNPs with PEGylation. Following IV administration, brush-like PEGylation show increased plasma protein adsorption when compared to club-shaped PEGylation or mushroom-like. Also, PEGylation influence LNPs size, its surface charge, and the capability of gene silencing. Next to extravasation, lightly PEGylated LNPs have shown enhanced activation and expansion of tumor resident antigen presenting cells when compared to largely PEGylated has shown reduced effects