Table 2 Potential applications of exosomes in the mRNA delivery
From: Exosome for mRNA delivery: strategies and therapeutic applications
Disease | Source cell line | Targeted moiety | Outcome | References |
|---|---|---|---|---|
Cancer | Breast cell | HchrR6 mRNA | Growth inhibition of HER2-positive breast cancer in human | [123] |
SKOV3 human ovarian cancer cells | CRISPR/Cas9 | Targeted accumulation in ovarian cancer and induction of apoptosis of cancer cells | [137] | |
Mesenchymal stromal cells (MSCs) from adipose tissue | yCD::UPRT mRNA | Drastic reduction in tumor burden | [138] | |
Dental pulp mesenchymal stem cells | yCD::UPRT mRNA tagged with iron | Caused tumor cell death | [139] | |
Infectious diseases | Lung cells | mRNA | Deposition of mRNA in bronchioles and parenchyma to treat lung issues associated with COVID | [135] |
Metabolic disorders | Adipose cells | Bmp7 | Improved anti-obesity potential | [97] |
HEK293T cells | miR-148a (an adipose relatively specific miRNA)-responsive PGC1α mRNA | Pronounced fat browning in the adipose tissue and less off-target effects | [121] | |
Parkinson’s disease | HEK-293 T cells | Catalase | Potent neuroprotective effect | [101] |