Fig. 31
From: Recent advances in gene delivery nanoplatforms based on spherical nucleic acids
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(A) Topical application of SNAs on rabbit ear scars. Note: “MWF” indicates 3 days a week “Monday, Wednesday, Friday”, when treatment was administered. (B) Average TGF-β1 expression level, as evaluated by densitometry and Western blot protein analysis, which was normalized to the untreated group and expressed as the mean ± SEM (N = 6). Significant differences were observed between treatment vs. untreated groups (*p < 0.05, **p < 0.01).C) Masson’s trichrome staining of scar ear tissues under diverse treatment conditions. Note: The red arrow shows the site of the magnified image. Scale bars = 100 μm. D) Graphic depiction of scar elevation index (SEI). E) Mean ± SEM of composite SEI in different treatment groups (N = 6). Significance differences between treatment groups and controls are indicated by *p < 0.05, **p < 0.01, ns = not significant).