Fig. 9

Mimicking cancer and endometriosis on the chip. (A) Organ-on-a-chip model of vascular-platelet crosstalk in ovarian cancer. Damaged blood vessels in ovarian cancer are adjacent to the tumor, and the two fluidic chambers in the chip (red: blood vessel chambers; blue: cancer cell chambers) are also in adjacent superimposed positions. Reproduced with permission [19]. Copyright 2020 The American Society of Hematology. (B) Engineering drawing of the microdevice containing two PDMS compartments separated by a thin porous membrane that reproduces the microarchitecture of the tumor-vascular interface (left). On the right, cross-sectional side view of the ovarian tumor microenvironment chip describes tissue organization inside the chip. Reproduced with permission [128]. (C) Model for simulating the interaction between endometrial stromal cells (ESCs) and human peritoneal mesothelial cells (HPMCs). Cells were inoculated in microchannels, and the straight microchannel was inoculated with ESCs (blue), and the U-shape microchannel was inoculated with HPMCs (green). Reproduced with permission [14]. Copyright 2012 The Royal Society of Chemistry. (D) Schematic of the microfluidic device used to study the proliferation and metabolic status of endometriotic 12Z cells. Green dye labelled live cells and red dye labelled dead cells. The device was used to test the effects of curcumin, plumbagin and atovaquone on 12Z cell viability. Reproduced with permission [137]. Copyright Society for Reproduction and Fertility 2023