Fig. 4

Imaging evaluation of NPs targeted therapy for plaque. (A) The treatment plan for atherosclerosis prevention and management. (B) Ultrasound imaging of aortic arch in early atherosclerotic mice and healthy mice (Scale bar = 2 mm). (C) H&E staining of aortic sinus in early atherosclerotic mice (Scale bar = 75 μm). (D) Ex vivo fluorescence images of the isolated aorta. (E, F) The quantitative average fluorescence intensity measurements for the aorta (E) and primary organs (F) across all experimental groups. Mean ± SD, n = 3, *p < 0.05. (G) Ultrasound images of abdominal aorta and aortic arch after treatment (Scale bar = 2 mm)