Table 3 Results of in vitro release fitting curve
From: Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation
Models | SR-SUS | SR-SUS-ISG | ||
|---|---|---|---|---|
Fitting equation | R2 | Fitting equation | R2 | |
Zero-order | A = 2.229 + 0.859t | 0.755 | A = 1.779 + 0.909t | 0.771 |
First-order | A = 7.160*(1-e− 0.685t) | 0.963 | A = 37.283*(1-e− 0.608t) | 0.998 |
Higuchi | A = 20.235*(t^0.5)-1.097 | 0.948 | A = 15.551*(t^0.5)-0.747 | 0.940 |
Ritger-peppas | A = 19.479*(t^0.498) | 0.946 | A = 14.975*(t^0.498) | 0.938 |