Table 5 Pharmacokinetic parameters of sirolimus nanosuspension and sirolimus nanogel after vertical administration in rabbits(n = 7, \(\stackrel{-}{x}\pm\)s)*p<0.05
From: Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation
Pharmacokinetic Parameters | SR-SUS | SR-SUS-ISG | Ratio ISG/SUS |
|---|---|---|---|
AUC(0−t)/ µg/L·h | 41.31 ± 12.20 | 174.88 ± 124.58* | 4.23 |
AUC(0−∞)/ µg/L·h | 43.99 ± 14.43 | 686.17 ± 1201.20 | 15.59 |
MRT(0−t)/h | 3.81 ± 0.52 | 5.81 ± 0.49* | - |
Tmax/h | 0.36 ± 0.10 | 0.23 ± 0.14 | - |
Cmax/ng/mL | 11.88 ± 3.78 | 33.42 ± 26.20 | 2.81 |