Fig. 7
In vivo profiles of conNK-EV and mNK-EV in subcutaneous tumor models after tail vein injection. A Fluorescence images of one representative mouse in each condition over time, depicting the circulation of fluorescent sEV and the accumulation into the focused tumor region (white circle). B The fluorescence intensities of tumors were recorded over time, normalized to the first fluorescence reading in each tumor, and plotted against time (n = 5). C The fluorescence intensity of mouse blood was plotted versus the sampling time, fitting into an exponential function (displayed as a dotted line in each graph panel), so the exponential decay constant was acquired for conversion into the circulation half-time (t1/2). D At 48 h p.i., mice were sacrificed, and major organs were harvested. The fluorescence intensity of each organ was recorded per tissue area and normalized to that of liver (n = 5). ns: no significance. *p < 0.05