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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

Fig. 6

Inhibitory effect of PAZ@Fe-MOF on TGFBR1-SMAD3-ATF6-TXNDC5 signaling axis. (A) Syngeneic murine 4T1 and xenograft human MDA-MB-231 breast cancer models were treated with Fe-MOF, PAZ or PAZ@Fe-MOF. Tumor tissues were collected and processed for RNA isolation. The mRNA expression of TGFBR1 and SMAD3 was analyzed using qRT-PCR. (B-C) Tumor tissues were lysates and then blotted with indicated antibodies. (D) The mRNA expression of ATF6 and TXNDC5 in tumor tissues was analyzed using qRT-PCR. (E-F) Tumor tissues were lysates and then blotted with indicated antibodies. (G-H) The effect of PAZ@Fe-MOF on M2-type chemokines (CCL17, CCL22 and CCL24) and anti-inflammatory factors (IL10 and TGF β) in tumor tissue homogenates

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Journal of Nanobiotechnology

ISSN: 1477-3155

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