Fig. 4

Biodistribution of M-Exos in the lungs after nebulization (A) in vivo imaging of the mice at 4 h and 1, 3, 5, and 7 days after DiR-labeled M-Exo nebulization. (B) quantitative analysis of fluorescence signals. (C) qPCR analysis the expression of TGF-β1 mRNA in the lung tissues of mice within 28 days. (D) qPCR analysis the expression of TGF-β1 mRNA in lung tissue 48 h after M-siTGF-β1 administration (N = 3)