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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Nebulized milk exosomes loaded with siTGF-β1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability

Fig. 5

M-siTGF-β1 alleviated BLM-induced destruction of lung structure and inflammation (A) Experimental design of mouse PF model induced by BLM. (B) Body weight changes in mice throughout the experimental cycle. (C) Comparative body weight analysis from initial to the study’s endpoint. (D) Survival curves. (E) Lung tissue morphology of mice. (F) Assessment of changes in lung tissue weight. (G) Histopathological analysis using H&E staining. (H and I) Identification of fibrosis through Masson and Sirius Red staining. (J) Quantification of collagen area via Masson staining. (K) qPCR detection of inflammation-related factor IL-6 mRNA expression in lung tissue. (L) Hydroxyproline quantification offered a measure of total collagen content (N = 3–5)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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