Fig. 7

Analysis of of inflammatory pathways. (a) the levels of ra biomarkers in serum (crp, ccp-ab, ana, and rf-ab). (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). (b) Serum concentration of pro-inflammatory cytokines (tnf-α、il-12、il-1β、ifn-γ andil-17a). (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). (c) if confirmed the expression level of akt, nf-κb and il-1β. Scale bars: 100 μm. (d) comparison of if expression levels among different groups. (^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001)