Skip to main content
Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus

Fig. 6

GDM-EVs induced insulin resistance through STAT3/FAM3A. (A) After 24 h exposure of THLE-2 cells to GDM-EVs or Normal-EVs, the levels of miR-1299 in cells were measured by qPCR analysis. The effects of Colivelin on recovery of glucose output (B) and gluconeogenic gene (C) in liver cells with treatment of GDM-EVs. (D) The effects of Colivelin on recovery of STAT3, FAM3A, P-STAT3, and P-AKT expression levels in cells exposed to GDM-EVs. (E) Statistical analysis of western blot results. Representative immunofluorescent staining of STAT3, FAM3A (F), and P-STAT3 (G) localization in the liver from mice injected GDM-EVs or Normal-EVs. (bar, 50 μm). Results are means ± SEM (n = 3–6). *p < 0.05, **p < 0.01, ***p < 0.001

Back to article page

Journal of Nanobiotechnology

ISSN: 1477-3155

Contact us