Fig. 7

MiR-1299 impairs insulin sensitivity through STAT3/FAM3A. (A-D) Glucose output and gluconeogenic gene in THLE-2 cells after transfection with miR-1299 mimics or inhibitor. (E) Expression of STAT3, FAM3A, P-STAT3, and P-AKT after overexpressing or inhibiting of miR-1299. (F) MiR-1299 directly targets STAT3. The binding site of the miRNA on its target was predicted by TargetScan. Results are means ± SEM (n = 3–6). *p < 0.05, **p < 0.01, ***p < 0.001. WT = wild type, MUT = mutation