Fig. 4

Molecular targets of curcumin on ROS, proliferation, apoptosis, and cell phase arrest. HER2, human epidermal growth factor receptor 2; MnSOD, manganese-dependent superoxide dismutase; GGTP, gamma-glutamyltranspeptidase; Nrf-2, nuclear factor 2–related factor; Fen1, Flap structure-specific endonuclease 1; CXCR4, chemokine receptor 4; uPAR, urokinase plasminogen activator receptor; FASN, fatty acid synthase; ACC, acetyl-CoA carboxylase; ICAM-1, intercellular adhesion molecule 1; uPA, urokinase plasminogen activator; MMP-9, matrix metalloproteinase 9; hTERT, telomerase reverse transcriptase; TRAIL, TNF-related apoptosis-inducing ligand. This figure was reprinted with permission from Ref [32], copyright 2016, Society for Laboratory Automation and Screening