Fig. 3
From: Nanobiotechnology boosts ferroptosis: opportunities and challenges
B, C Were reproduced from ref. [82] with permission. Copyright 2019, American Chemical Society)
A Schematic representation of NDDSs enhanced the bioavailability of ferroptosis-related drugs. In the absence of a nanoparticle delivery carrier, sorafenib exhibits poor water solubility in blood, and siRNA is easily identified and cleared by macrophages, which decreases their bioavailability. However, the use of NDDSs (depicted as HDP in the diagram), enhances the solubility of drugs, prolongs their circulation time, and increases their bioavailability. B The zeta potentials of Pa-M/Ti-NCs in 10% FBS and PBS, little change was found during more than 2Â weeks. C In vivo pharmacokinetic curves during 36Â h after injection of different formulations