Fig. 9
From: Nanobiotechnology boosts ferroptosis: opportunities and challenges
(reproduced from ref. [154] with permission. Copyright 2023, Elsevier)
A Schematic representation of nanobiotechnology combines ferroptosis with phototherapy. GNRs, under the effect of NIR, generate high temperature to kill tumor cells and promote the release of drugs. The released FAC and JQ-1 respectively accelerates the Fenton reaction and inhibits GPX4, synergistically inducing ferroptosis. B The live/dead cell cytotoxicity analysis of 4T1 cells stained by AM/PI after incubation with various groups (scale bar = 100 mm for all panels). C CLSM images of ROS generation after 4T1 cells were treated with different formulations. Scale bar = 25 mm. D Quantitative analysis of the ROS intensity in various conditions. E Cytotoxicity analysis of 4T1 cells treated with various formulations. F Cytotoxicity analysis of 4T1 cells treated with various concentrations of GNRs@JF/ZIF-8