Fig. 8
Induction of potent antitumor memory immune response through combination therapy of NBTXR3, PRT, and αPD1. A Presents the percentages of CD4 + and CD8 + memory T cells in the blood. B Demonstrates the growth curves of tumors in mice that survived and were rechallenged with 344SQR, 344SQP, and 393P cells. Memory T cell populations in the blood of these survivor mice that received NBTXR3 + PRT + αPD1 were characterized 93 days post PRT. These mice were then subjected to a rechallenge with 5X104 344SQR cells 102 days post PRT, 5X105 344SQP cells 157 days post PRT, and 5 × 105 393P cells on 247 days post PRT. Percentages of blood memory T cells were analyzed using two-tailed t-tests. The data are presented as mean ± SEM. The threshold for statistical significance was set at P < 0.05. Indicators of statistical significance are as follows: *P < 0.05; **P < 0.01; ***P < 0.001. NS denotes findings that were not significant