Fig. 4

illustrates the following processes: a Conventional type 1 dendritic cells (cDC1s) capture and deliver tumor antigens to tumor-draining lymph nodes (TDLNs), where they activate naïve CD8 + T cells, leading to the development of cytotoxic effector CD8 + T cells. This image is copyrighted by the Francis Crick Institute in 2018 [231]. b TDLNs exhibit a high concentration of tumor-specific PD-1 + T cells. Inhibiting PD-L1 in TDLNs results in the formation of progenitor-exhausted T cells, which then infiltrate the tumor, thereby boosting antitumor immunity. This part of the figure is copyrighted by Elsevier Inc. in 2020 [232]. Definitions included in this description are cDC1 for conventional type 1 dendritic cells, and TDLN for tumor-draining lymph node