Fig. 4

Bacterial-fungal interkingdom co-occurrence networks. A Co-occurrence network analysis of full dataset (n = 216) showing microbial interkingdom network patterns for different groups. B Number of bacterial–bacterial (BB), bacterial–fungal (BF), and fungal–fungal (FF) correlations in the control (CK) and CNS-treated (T1 and T2) networks. "P" and "N" indicate positive and negative correlations, respectively. C Comparison of node-level topological features (degree and closeness centrality) between bacterial and fungal taxa at different groups. Asterisks indicate significant differences (nonparametric Wilcoxon rank test, P ≤ 0.05) between the CNS-treated and control (CK) samples, and two asterisks indicate P < 0.01