Fig. 2
(Adopted from [38])
Structure of lipid nanoparticle (LNP) encapsulating nucleic acids. A Compact nanostructured core. The LNPs exhibit a compact, electron-rich core where the siRNA is tangled with positively charged lipids forming inverted micelle structures, enclosed by cholesterol and helper lipids; B the multilamellar assembly features an external bilayer and a dense inner core; C ‘Bleb’ configuration. The cationic lipid predominantly interacts with the mRNA, creating a solid core, while the helper lipid is mainly partitioned into a ‘bleb’ bilayer