Table 4 Recent LNP-RNA therapeutics in clinical trials

Lipo-MERIT

NCT02410733

I

Melanoma

03/2015

VAL-506440

NCT03076385

I

Influenza

12/2015

VAL-339851

NCT03345043

I

Influenza

05/2016

IVAC_W_bre1_uID

NCT02316457

I

TNBC

10/2016

mRNA-1325

NCT03014089

I

zika virus

12/2016

mRNA-4157

NCT03313778

I

Solid tumors

08/2017

mRNA-2416

NCT03323398

I/II

Relapsed/refractory solid tumor malignancies or lymphoma/ovarian cancer

08/2017

CTX001

NCT03655678

III

TDT

09/2018

Rabipur®

NCT03713086

I

Rabies

10/2018

mRNA-2752

NCT03739931

I

Relapsed/refractory solid tumor malignancies or lymphoma

11/2018

mRNA-4157

NCT03897881

IIb

Stage III/IV melanoma

07/2019

PCV

NCT03908671

I

Esophageal cancer/non-small cell lung cancer

10/2019

PCV

NCT04161755

I

Pancreatic cancer

12/2019

mRNA-1273

NCT04283461

I

COVID-19

03/2020

NR

NCT04426669

I/II

GI cancer

05/2020

ARCT-810

NCT04416126

I

OTCD

06/2020

ARCT-021

NCT04480957

I/II

COVID-19

08/2020

NTLA-2001

NCT04601051

I

TTR-FAP/TTR-CM/wild-type transthyretin cardiac amyloidosis

11/2020

ARCT-810

NCT04442347

I

OTCD

11/2020

1 µg CoV2 SAM (LNP)

NCT04758962

I

Virus diseases

02/2021

mRNA-1273

NCT04785144

I

COVID-19

03/2021

Moderna COVID-19 Vaccine

NCT04811664

III

COVID-19

03/2021

BNT162b2

NCT04824638

II

COVID-19

03/2021

ChAdV68-S

NCT04776317

I

COVID-19

03/2021

mRNA-1273

NCT04805125

III

COVID-19

04/2021

BNT162b2/mRNA-1273

NCT04900467

NR

COVID-19

05/2021

NR

NCT05171959

NR

COVID-19

05/2021

mRNA-1273 SARS-CoV-2 vaccine

NCT04894435

II

COVID-19

05/2021

ChulaCov19 vaccine

NCT04566276

I/II

COVID-19

05/2021

mRNA-1893

NCT04917861

II

Zika Virus

06/2021

SARS-CoV-2 mRNA vaccine

NCT04847102

III

COVID-19

07/2021

mRNA-1647

NCT05085366

III

CMV

10/2021

Amaretto

NCT04981691

I

Refractory malignant solid neoplasm

10/2021

BNT162b2

NCT04961229

IV

COVID-19

10/2021

mRNA-1345

NCT05127434

II/III

RSV-LRTD

11/2021

LNP-nCOV saRNA-02 Vaccine

NCT04934111

I

COVID-19

12/2021

BNT162b2

NCT05124171

III

COVID-19

12/2021

Moderna mRNA-1273

NCT05168813

II/III

HIV/COVID-19

12/2021

NTLA-2002

NCT05120830

I/II

HAE

12/2021

mRNA-1189

NCT05164094

I

EBV

12/2021

BNT141

NCT04683939

I/IIa

Multiple solid tumors

01/2022

WU-CART-007

NCT04984356

I/II

T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma

01/2022

mRNA -1574

NCT05217641

I

HIV

02/2022

AS03

NCT05289037

II

COVID-19

03/2022

mRNA-1273

NCT05315362

II

COVID-19

05/2022

mRNA-1644

NCT05414786

I

AIDS

05/2022

mRNA-3745

NCT05095727

I/II

GSD

06/2022

mRNA-1010

NCT05415462

III

Seasonal influenza

06/2022

ARCT-810

NCT05526066

II

OTCD

07/2022

mRNA -1215

NCT05398796

I

Nipah virus

07/2022

BEAM-101

NCT05456880

I/II

SCD

08/2022

OTX-2002

NCT05497453

I/II

HCC/solid tumor

08/2022

mRNA-1468

NCT05701800

I/II

Herpes zoster

01/2023

LVRNA009

NCT05682638

III

COVID-19

01/2023

ARCT-032

NCT05712538

I

CF

02/2023

PTX-COVID19-B

NCT05534035

III

COVID-19

02/2023

PTX-COVID19-B

NCT05534048

III

COVID-19

02/2023

HBV vaccine

NCT05738447

I

Liver cancer/ HCC

02/2023

mRNA-1345/mRNA-1365

NCT05743881

I

RSV/HMPV

02/2023

LVRNA010

NCT05599802

I

COVID-19

02/2023

NR

NCT05745545

NR

COVID-19

02/2023

GLB-COV2-043

NCT05602961

I/II

COVID-19

02/2023

Moderna/Novavax

NCT05658523

III

COVID-19

02/2023

mRNA-1011.1/mRNA-1011.2/mRNA-1012.1

NCT05827068

I/II

Seasonal influenza

03/2023

JCXH-221

NCT05743335

I/II

COVID-19

03/2023

RVM-V001/RVM-V002

NCT05788185

I/II

COVID-19

03/2023

LVRNA021

NCT05812014

III

COVID-19

03/2023

mRNA-1283.222

NCT05815498

III

COVID-19

03/2023

Novavax

NCT05875701

III

COVID-19

03/2023

mRNA-1083

NCT05827926

I/II

COVID-19/influenza

04/2023

H3 mRNA / LNP Vaccine

NCT05829356

I

Influenza

04/2023

NR

NCT05761717

NR

Hepatocellular carcinoma

04/2023

mRNA-1195

NCT05831111

I

EBV

04/2023

mRNA-1010

NCT05827978

III

Seasonal influenza

04/2023

GSK4382276A

NCT05823974

I/II

Influenza

04/2023

H1ssF-3928

NCT05755620

I

Influenza

04/2023

mRNA-1647

NCT05683457

II

CMV

04/2023

LVRNA009

NCT05428592

III

COVID-19

04/2023

LVRNA012

NCT05549206

NR

COVID-19

04/2023

RQ3027/RQ3025

NCT05907044

NR

COVID-19

05/2023

BNT162b2/Sanofi

NCT05749926

III

COVID-19

05/2023

SWIM816

NCT05911087

II/III

COVID-19

06/2023

RH109

NCT05609045

I

COVID-19

06/2023

mRNA-1010

NCT05868382

II

Influenza

05/2023

TCR-T

NCT05905731

I

Chronic hepatitis B

06/2023

TI-0010

NCT06205524

I

COVID-19

07/2023

V3G CH848 Pr-NP1 60mcg

NCT05903339

I

HIV

08/2023

MT-302 (A)

NCT05969041

I

Epithelial tumors, malignant

08/2023

DCVC H1 HA mRNA vaccine

NCT05945485

I

Influenza

10/2023

RSV/hMPV mRNA LNP

NCT06237296

I

RSV/HMPV

01/2024

NR

NCT05387317

III

COVID-19

04/2024