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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation

Fig. 2

Apelin-13 promotes functional recovery in rats with SCI Rats were randomly allocated into five groups: sham surgery, SCI modeling plus vehicle treatment, SCI modeling plus Apelin-13 treatment, SCI modeling plus Apelin-13 treatment and scramble siRNA transduction, and SCI modeling plus Apelin-13 treatment and APJ siRNA transduction. (A) After 28 days of modeling and treatment, spinal cord tissues were collected from model rats sacrificed under anesthesia and examined for histopathological characteristics using H&E staining. (B-C) The BBB Locomotor Rating Scale and inclined-plane test were used to evaluate the behavioral outcomes and motor ability of rats from different groups at days 0 (pre-surgery), 1, 5, 7, 10, 14, 21, and 28. (D) After 28 days of modeling and treatment, the protein levels of Apelin-13 and APJ in spinal cord tissues were determined using Immunoblotting. n = 6 or 3, ** p < 0.01, vs. sham group; ## p < 0.01, vs. SCI + vehicle group; && p < 0.01, vs. SCI + Apelin-13 group

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Journal of Nanobiotechnology

ISSN: 1477-3155

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