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Table 5 Pharmacokinetic parameters of HA*SAS@DXP-L

From: Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle

 

Healthy

Inflammation

Combination

t1/2 (h)

0.249 ± 0.010

0.160 ± 0.008

0.244 ± 0.030

Ke (1/h)

2.783 ± 0.117

4.341 ± 0.193

2.869 ± 0.037

V1 (L/kg)

0.008 ± 0.000

0.008 ± 0.001

0.008 ± 0.000

CL (L/h/kg)

0.023 ± 0.001

0.033 ± 0.002

0.023 ± 0.002

AUC(0-t) (mg/L*h)

408.401 ± 9.210

278.595 ± 13.078

403.644 ± 38.830

AUC(0-∞) (mg/L*h)

437.630 ± 8.784

306.967 ± 13.262

432.067 ± 38.531

  1. t1/2, Half-life; Ke, Elimination rate constant; V1, Volume of distribution at steady state; CL, Clearance; AUC(0-t), Area Under the Curve from 0 to t; AUC(0-∞), Area Under the Curve from 0 to infinity
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Journal of Nanobiotechnology

ISSN: 1477-3155

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