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Table 6 Pharmacokinetic parameters of PEG2,5 K@MLP-L

From: Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle

 

Healthy

Inflammation

Combination

t1/2 (h)

1.194 ± 0.055

0.399 ± 0.029

1.367 ± 0.082

Ke (1/h)

0.582 ± 0.027

1.742 ± 0.130

0.508 ± 0.031

V1 (L/kg)

0.369 ± 0.002

0.295 ± 0.012

0.372 ± 0.005

CL (L/h/kg)

0.215 ± 0.010

0.512 ± 0.017

0.189 ± 0.009

AUC(0-t) (mg/L*h)

45.517 ± 2.041

18.684 ± 0.679

51.613 ± 2.320

AUC(0-∞) (mg/L*h)

46.598 ± 2.110

19.553 ± 0.655

52.989 ± 2.471

  1. t1/2, Half-life; Ke, Elimination rate constant; V1, Volume of distribution at steady state; CL, Clearance; AUC(0-t), Area Under the Curve from 0 to t; AUC(0-∞), Area Under the Curve from 0 to infinity
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Journal of Nanobiotechnology

ISSN: 1477-3155

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