Fig. 7
Role of EVs derived from macrophages after different treatments in PROM. (A) Representative fluorescence imaging of various EVs in the whole-body from PROM mice. (B) Analysis of the PROM time after various EV treatments in the mouse model. C and D. Mesenchymal marker (N-cadherin) and epithelial marker (E-cadherin) of the native AECs were analyzed by immunofluorescence. Mesenchymal marker (N-cadherin) was increased significantly after treatment with the M0-EVsmiRs, M0-EVssiRs, and M1-EVs, but the opposite trend was found with the epithelial marker. N = 3. White asterisk: fetal surface of the amnion; scale bar = 200 μm. ns, not significant, *P < 0.05, **P < 0.01