Fig. 11

Effects of CON-EV and IL-6-EV on synovitis and mt-ND3 in vivo. (A) HE staining of the synovium and (B) synovitis score in each group. (C) Immunohistochemical staining of IL-6 in the synovium and (D) statistical analysis. (E) Immunofluorescence staining and quantitative analysis of (F) CD206 and (G) iNOS in the synovium. (H) The expression of mt-ND3 in synovial macrophages from each group was detected by immunofluorescence. (I) Statistical analysis of mt-ND3 fluorescence intensity in vivo. All data are shown as means ± standard deviations (n = 5), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001