Fig. 5

Treatment of PD mice with UDCA-NVs-TPP. a) A schematic diagram depicting the treatment of PD mice with UDCA-NVs-TPP, as well as behavioral testing and related experimental procedures conducted on the mice. b) Suspension Test of mice in Control group, PD group, UDCA group, UDCA-NVs group, and UDCA-NVs-TPP group (n = 3). c) Pole Climbing Test conducted on mice from Control group, PD group, UDCA group, UDCA-NVs group, and UDCA-NVs-TPP group (n = 3). d) Immunoreactivity of TH in the striatum was assessed in mice from the Control, PD, UDCA, UDCA-NVs, and UDCA-NVs-TPP groups (n = 3). e) CLSM images showing TH immunofluorescence in the striatum were obtained from mice in the Control, PD, UDCA-NVs, and UDCA-NVs-TPP groups, along with CLSM images of FITC-labeled UDCA-NVs and UDCA-NVs-TPP in the striatum; Blue: cell nuclei; green: FITC-labeled nanoparticles; red: TH-positive neurons. f) Quantitative analysis of TH immunoreactivity in the striatum of mice (n = 3). g) Quantitative analysis of Cy3-labeled anti-TH antibody. h) H&E staining was performed on the major organs to evaluate the biocompatibility of nanoparticles (n = 3)