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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications

Fig. 5

Overview of the communication network between the liver and adipose tissue mediated by EVs.Adipose tissue secretes EVs that have an impact on insulin function, liver disorders, and cold acclimatization. EVs produced from the liver, in turn, have a role in controlling adipose tissue remodeling and glucose homeostasis. The relationship between EVs and metabolic balance as well as liver disorders is shown in the liver-adipose axis. Abbreviation: Srebf1: sterol regulatory element binding transcription factor 1; PTEN: phosphatase and tensin homolog deleted on chromosome 10; ATM: adipose tissue macrophage; PPARγ: peroxisome proliferator-activated receptor gamma; Sirt1: silent information regulator 1; NAFLD: nonalcoholic fatty liver disease; PHLPP2; PH domain and leucine rich repeat protein phosphatase 2; AS160: Akt substrate of 160 kDa; GLUT4: glucose transporter 4; TM4SF5: transmembrane 4 L six family member 5

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Journal of Nanobiotechnology

ISSN: 1477-3155

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