Fig. 7

In Vivo Neuroprotective Effects of NM@PB-Ce in an AD Mouse Model. A Western blot analysis quantifying the expression levels of NLRP3 inflammasome components (NLRP3, caspase-1, and GSDMD-NT) and pro-inflammatory cytokines (IL-18 and IL-1β) across experimental groups. B–F Quantification of NLRP3, caspase-1, GSDMD-NT, IL-18, and IL-1β protein expression levels in each treatment group by ELISA. n = 6 per group. G Western blot analysis of amyloid-β (Aβ) protein expression levels across experimental groups. H Quantification of Aβ protein levels in each treatment group by ELISA. I CLSM visualization of intracranial ASC, caspase-1, GFAP, and Iba-1 expression following various treatments. J CLSM imaging of intracranial Aβ accumulation and Th-T fluorescence intensity after different treatment regimens. K Representative Golgi-Cox-stained images of dendritic spines in the CA1 region of the hippocampus across experimental groups. L Ultrastructural analysis of mitochondrial morphology in hippocampal neurons across different experimental groups, as observed using TEM. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001