Table 1 The comparison of PDC and ADCs
Properties | PDC | ADC |
|---|---|---|
Molecule weight | ~ 2000-20,000 Da [17] | >150,000 Da [5] |
Pharmacokinetic | A shorter half-life and undergoes rapid renal clearance with less toxic to the bone marrow and liver | A longer half-life than PDCs and undergoes nonspecific liver and reticuloendothelial system uptake, leading to potential dose-limiting hepatotoxicity |
Manufacture cost | Low (It can be expressed in situ or chemically synthesized for simple production and easy scale-up)[18] | High (Relatively difficult to manufacture and costly to produce and qualify)[19] |
Quality control complexity | Low (homogeneity, simpler analytical methods)[18] | High (heterogeneity, advanced analytical methods)[19] |
Tumor penetration | Yes | Limited |
Immunogenicity | Low | Some are high |
Chemical synthesis | Yes | No |
Cancer targets | Variety of targets located on cell surface or intracellular protein | Limited to cell surface receptors |