Fig. 7
From: ZnO-Cu/Mn nanozyme for rescuing the intestinal homeostasis in Salmonella-induced colitis
The antibacterial and anti-inflammatory effect of ZnO-CM in vivo in a Salmonella-infected enteritis model. Groups are divided into Control, Model, ZnO (50 mg/kg), ZnO-CM-L (25 mg/kg), and ZnO-CM-H (50 mg/kg). (A) Schematic of the mouse model establishment and subsequent testing of antibacterial effects in the colon and small intestine. (B) Mortality curves (n = 20). (C) curves of body weight in mice. (D) Comparison of colon length after treatment of Salmonella infection. (E) Quantification of colon length. (F) ex vivo visceral imaging showing bacterial concentration and distribution. (G.H) groups of small intestine and colon bacteria smear photos and quantification after treatment. (I) immunofluorescence observations tissue section distribution of bacteria. (J) Hematoxylin-eosin (HE) staining of tissue sections of the small intestine and colon. (K.L) expression levels of inflammation-related proteins. n = 10, * p < 0.05, ** p < 0.01, *** p < 0.001