Fig. 7

Inhibition of lung metastasis by CussOMEp (300 µg per mouse) in combination with αPD-1 (1 mg/kg). (a) Schematic illustration of treatment schedule. (b, c) Growth curves showing total tumor burden (b) and individual tumor sizes (c) for all experimental groups (n = 8). (d, e) Representative bioluminescence images (d) and quantitative analysis (e) on days 21, 25, and 30. (f, g) Representative lung tissue images stained with India ink (f) and H&E (g), with tumors indicated (Tu). (h) Survival rates of mice under different treatment conditions. Statistical significance is indicated as **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns (not significant; P > 0.05), determined using one-way ANOVA followed by Dunnett’s multiple comparisons test. Data are presented as mean ± s.d