Fig. 3

The biodistribution and degradation of SP. (A) The schematic diagram of SP degradation in vitro. (B) Bright-field (Scale Bar = 10 μm) and SEM (Scale Bar = 5 μm) images of DOX-SP after degradation in vitro for 0, 7, 14 and 28 days, respectively. (C) Fluorescence images and relative liver tissue H&E staining of DOX-SP after embolization in vivo for 1 h, 7 days, 14 days and 28 days, respectively. Yellow degradation products of SP were observed in the liver (black arrow). Scale Bar = 100 μm. (D) TEM images of the liver tissue after degradation in vivo for 14 days (left) and 2 months (right) following embolization. Degradation products of SP were observed in the liver cell (yellow arrow). Scale Bar = 5 μm