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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs

Fig. 3

Bioinformatic analysis of the targeting relationship between miRNA-20b and RORγt/STAT3 and their inflammatory levels. (A) Schematic diagram of the miRNA-20b and RORγt/STAT3 pathway. (B) Venn diagram representation. (C) Dual-luciferase reporter gene assay for miRNA-20b and STAT3. (D, E, F, G) Qualitative and quantitative analysis of Th17 cell markers in different groups. (H, I, J, K, L, M, N, O) Expression levels of TGF-β, IL-17, IL-6, IL-21, Socs3, IL-10, IL-2, and IL-4. G1: CD4 + T; G2: OE-RORγtCD4 + T; G3: BMSCs + RORγtCD4 + T; G4: OE-miRNA-20b-BMSCs + OE-RORγtCD4 + T; G5: SeNPs@CS + OE-miRNA-20b-BMSCs + OE-RORγt CD4 + T. ***(P < 0.001), **(P < 0.01), *(P < 0.05)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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